Tutorial on multivariate meta-analysis

This page contains the necessary material for a hands-on tutorial on multivariate meta-analysis using Stata. The tutorial will be offered as a lecture within the course "Systematic Reviews and Meta-analysis", which is a part of the curriculum leading towards a MSc degree in "Clinical Investigation" at the New York University School of Medicine. The course is organised by Dr Sripal Bangalore.







  • van Houwelingen HC, Arends LR, Stijnen T. Advanced methods in meta-analysis: multivariate approach and meta-regression. Stat Med. 2002;21(4):589-624.[PDF]
  • Riley RD, Thompson JR, Abrams KR (2008) An alternative model for bivariate random-effects meta-analysis when the within-study correlations are unknown. Biostatistics 9(1): 172-186 [PDF]
  • Riley RD, Abrams KR, Sutton AJ, Lambert PC, Thompson JR. Bivariate random-effects meta-analysis and the estimation of between-study correlation. BMC Med Res Methodol. 2007 12;7:3. [PDF]
  • Berkey CS, Hoaglin DC, Antczak-Bouckoms A, Mosteller F, Colditz GA (1998) Meta-analysis of multiple outcomes by regression with random effects. Stat Med 17(22): 2537-2550
  • Harbord RM, Deeks JJ, Egger M, Whiting P, Sterne JA (2007) A unification of models for meta-analysis of diagnostic accuracy studies. Biostatistics 8(2): 239-251 [PDF]
  • Higgins JP, Whitehead A (1996) Borrowing strength from external trials in a meta-analysis. Stat Med 15(24): 2733-2749
  • Lu G, Ades AE (2004) Combination of direct and indirect evidence in mixed treatment comparisons. Stat Med 23(20): 3105-3124
  • Arends LR, Hamza TH, van Houwelingen JC, Heijenbrok-Kal MH, Hunink MG, Stijnen T. Bivariate random effects meta-analysis of ROC curves. Med Decis Making 2008, 28(5):621-638.
  • Jackson D, Riley R, White IR.Multivariate meta-analysis: Potential and promise. Stat Med. 2011 Jan 26. doi: 10.1002/sim.4172. [Epub ahead of print]
  • Jackson D, White IR, Thompson SG: Extending DerSimonian and Laird's methodology to perform multivariate random effects meta-analyses. Stat Med 2010, 29:1282-129
  • Bagos PG. On the covariance of two correlated log-Odds Ratios. Statistics in Medicine. 2012 [PDF]
  • Bagos PG. A unification of multivariate methods for meta-analysis of genetic association studies. 2008, Statistical Applications in Genetics and Molecular Biology, 7(1), Article 13 [PDF]
  • Minelli C, Thompson JR, Abrams KR, Thakkinstian A, Attia J (2005) The choice of a genetic model in the meta-analysis of molecular association studies. Int J Epidemiol 34(6): 1319-1328 [PDF]


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